O033 Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome

Abstract Background Autonomic dysfunction has been implicated in the pathophysiology of Sudden Infant Death Syndrome (SIDS). Butyrylcholinesterase (BChE) is an enzyme cholinergic system, a major branch autonomic and may provide measure (dys)function. This study was undertaken to evaluate BChE infants young children who had died from SIDS or Unexpected Death. Methods We measured specific activity (BChEsa) eluate 5μL spots punched dried blood (DBS) taken at birth as part newborn screening program. Results for each 67 SUDI deaths classified by coroner (aged 1 week – 104 weeks) = Cases, were compared 10 date - gender-matched surviving controls (Controls), with five cases reclassified meet criteria SIDS. Findings Conditional logistic regression showed that groups where reported “SIDS death” there strong evidence lower BChEsa associated death (OR=0·73 per U/mg, 95% CI 0·60 0·89, P=0·0014), whereas “Non-SIDS group no linear association between (OR=1·001 0·89 1·13, P=0·99). Conclusion BChEsa, DBS 2-3 days after birth, babies subsequently other Non-SIDS deaths. conclude previously unidentified deficit, identifiable abnormal present represents measurable, vulnerability prior their death.